LC-MS Aufreinigung mit Magnetic Beads erlaubt hohe Reinheit

MagSiMUS – LC/MS sample preparation with magnetic beads

Advanced Solution for LC/MS Sample Preparation

The new magnetic bead based MagSiMUS-system for LC/MS sample preparation developed by our Dutch partner MagnaMedics BV reaches beyond limits. It offers many major advantages compared to existing methods:

– Easy to automate
– No centrifugation or vacuum system required
– Short hands-on time
– Fast and standardised protocols
– Kits for analyte panels for efficient and cost saving work routines
– Optionally available inclusive liquid handler with tracking options

The Principle

The basic idea of MagSiMUS can be best described as „negative selection“ (see below). The smart thing is that MagSiMUS replaces filtration or centrifugation by simple pipetting steps!

The system can be used for pharmaceutical research and in clinical diagnostics as well. There are already many kits and panels available for clinical parameters like immunosuppressants, TDM, vitamines with more to come soon.

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The issue

LC/MS is one of the most specific and sensitive analytical methods available. However, the crucial point is the sample preparation. Current methods like SPE or LLE are quite expensive and inflexible and also very difficult to automate. This bottleneck limits the wider use of LC/MS for diagnostic parameters like e.g. immunosuppressants, steroids, TDM or vitamins and HTS research applications.

The solution

The new magnetic bead-based MagSiMUS-system for LC/MS sample preparation developed by our Dutch partner MagnaMedics BV removes these limits. It offers many major advantages compared to existing methods:

– Easy to automate
– No centrifugation or vacuum system required
– Short hands-on time
– Fast and standardized protocols
– Kits for analyte panels for efficient and cost-saving work routines
– Optionally available inclusive liquid handler with tracking options

The principle of MagSiMUS

The basic idea of MagSiMUS can be best described as „negative selection“ (see below). The smart thing is that MagSiMUS replaces filtration or centrifugation by simple pipetting steps as shown in the graphics below. The great advantage of this smart solution is the easy handling, either with manual pipettes or with the fully validated and automated MagSiMUS^DXpipetting station or any automated liquid handler to increase the throughput.

There are already kis available for many clinical parameters like immunosuppressants, TDM, vitamine and many more.

Benefits of the MagSiMUS sample preparation

Fast processing (about 40 min/96 samples)
Integrated automation philosophy
Low input volumes required (25 µl blood/ 50 µl serum)
Reduced consumption of reagents and reference material
High precision and excellent LC/MS signal-to-noise ratio
High reproducibility (low CV)
Innovative hardware solutions (MagSiMUSDX, LIQUIDATOR96)

The MagSiMUS Kits

Pipetting solutions for MagSiMUS

MagSiMUS^DX for fully automated sample preparation

One major advantage of MagSiMUS is that it is so easy to automate. This opens the prespective to makeLC/MS sample preparation an extremely safew routine process, e.g with the MagSiMUS^DX handler with full sample tracking.

The system is designed for easy programming and high flexibility. With only a few clicks it can be adjusted to either work with single tubes or 96 well plates, depending on the throughput. Please contact us for furhter information.

LIQUIDATOR96® – manual pipettor with 96 channels

Our 96-channel pipettor LIQUIDATOR96®. is a very powerful instrument to work with 96 well plates. With only one stroke you can add samples buffers to all 96 wells. It is also ideal to simultaneously remove supernatants as you can very accurately adjust how deep the pipette tips submerge.

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