MagSiMUS

LC/MS is one of the most specific and sensitive analytical methods available. However, the crucial point is the sample preparation. Current methods like SPE or LLE are quite expensive and inflexible and also very difficult to automate. This bottleneck limits the wider use of LC/MS for diagnostic parameters like e.g. immunosuppressants, steroids, TDM or vitamins and HTS research applications.

The new magnetic bead-based MagSiMUS-system for LC/MS sample preparation developed by our Dutch partner MagnaMedics BV removes these limits. It offers many major advantages compared to existing methods:

– Easy to automate
– No centrifugation or vacuum system required
– Short hands-on time
– Fast and standardized protocols
– Kits for analyte panels for efficient and cost-saving work routines
– Optionally available inclusive liquid handler with tracking options

The basic idea of MagSiMUS can be best described as „negative selection“ (see below). The smart thing is that MagSiMUS replaces filtration or centrifugation by simple pipetting steps as shown in the graphics below. The great advantage of this smart solution is the easy handling, either with manual pipettes or with the fully validated and automated MagSiMUS^DX pipetting station or any automated liquid handler to increase the throughput.

There are already kis available for many clinical parameters like immunosuppressants, TDM, vitamine and many more.